For many people, life is often a concern of ourselves.  We care how we feel, what we think of ourselves, what others think of us, what we want.  All of these things are meaningless.  God does not wish for us to think of ourselves, but He also does not want us to forget out feelings.  The point is that we don't let ourselves get in the way of the meaning of life and the path that God lays before us.  Here in America, we are concerned with finding a "good job" so that we can earn money and live comfortable by our own security.  People tell us this is wise; however, does it keep us from really knowing and understanding and doing the things God calls us to?  God is worth so much more than we know or can understand or comprehend.  He is more complicated than the troubles of a relationship or as confusing as the unpredictable.  We don't know Him.  He is a mystery.  We will spend eternity working to know Him better only to find there is no end.  Who are we to question God?  Who are we to make decisions for our lives when we don't understand how God created the world? You could have all the wisdom in the world or be at the bottoms of despair, but I tell you, you will be the same as the man next to you under the face of God.  You will be judged by a perfect God.  You will not understand why.  If you enter through the gates of Heaven, you will only know.  You will cry and not be able to explain.  You will be full of joy, peace and happiness.  Even so, if you enter down into the gates of Hell you will not comprehend, but just know.  And you will rebuke God for it.  You will hate Him with your whole soul, and you will not wish to escape from all the physical and emotional pain that you will endure every second of everyday for eternity.  For God has left you and has turned His back on you and has denied you your existence.  And  it will be just.  It will be right and it will be real.
Remember, you are nothing without Him.  There is no meaning without Him.  And if you deny the Lord, you deny yourself the reason for living.